Monistat Soothing Care Chafing Relief Powder-Gel is easy to apply - just squeeze a small amount of gel onto fingertips and rub onto skin. The gel dries quickly, drying down to what feels like a silky smooth barrier over the sensitive skin on your thighs. There's no really discernable fragrance, and it's non-irritating. This means you can apply it to skin that is already chafed just as effectively as to prevent chafing. I've found it to be long lasting- up to 8 hours or so.
In a pinch, I've also used stick deodorant (gel doesn't work well) - swiping it over my thighs. It doesn't last as long as the Monistat product, but does the job pretty well.
If you're someone who shies away from skirts and dresses thanks to chafing issues, this product just might expand your wardrobe while decreasing discomfort. You can buy it at most drugstores, and online at drugstore.com.